Advances in the effect of neurovascular unit in retinal physiological and pathological process
10.3760/cma.j.cn511434-20210111-00013
- VernacularTitle:神经血管单元在视网膜生理及病理过程中的作用研究进展
- Author:
Xinyuan HUANG
1
;
Yan SHAO
;
Xiaorong LI
Author Information
1. 天津医科大学眼科医院、眼视光学院、眼科研究所 天津市视网膜功能与疾病重点实验室天津市眼科学与视觉科学国际联合研究中心, 天津 300384
- Keywords:
Retinal diseases;
Review;
Neurovascular unit
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(2):168-172
- CountryChina
- Language:Chinese
-
Abstract:
Neurovascular unit (NVU) refers to a functional complex of neural cells and vasculature, which plays an important role in maintaining retinal homeostasis and matching metabolic demands. In physiological situation, retinal NVU mainly exerts two effects: (1) maintaining blood-retinal barrier for retinal homeostasis maintenance; (2) regulating local blood flow to meet metabolic and functional demands of the retina. The pathological changes in retinal diseases are reflected in each functional part of retinal NVU, including cell-cell connections, signal pathways, metabolic activities and cellular functions. However, the main pattern and manifestation of NVU impairment differs among retinal diseases due to different etiologies. At present, understanding on retinal NVU is still insufficient, and its clinical application is even more limited. Further application in the diagnosis and treatment of retinal diseases is an important direction for future research on NVU.
