Target inhibition of Toll-like receptor 4 signaling pathway and necrotizing enterocolitis
10.3760/cma.j.cn113903-20210802-00672
- VernacularTitle:Toll样受体4信号通路靶点抑制与新生儿坏死性小肠结肠炎的关系
- Author:
Dabin HUANG
1
;
Wei ZHOU
Author Information
1. 广州医科大学附属广州市妇女儿童医疗中心新生儿科，广州 510120
- Keywords:
Enterocolitis, necrotizing;
Toll-like receptor 4;
Signal transduction;
Infant, newborn
- From:
Chinese Journal of Perinatal Medicine
2022;25(1):67-71
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of neonatal necrotizing enterocolitis (NEC) is still unclear. Toll-like receptor 4 (TLR4) signaling pathway, mediated by TLR4 in the intestinal epithelial cells, is considered to play an important role in activating inflammatory storm in NEC. This paper elaborates the association between NEC and the inhibition of TLR4 signal pathway and its upstream and downstream signal targets, critical pattern recognition receptors, and negative regulation of TLR4 by certain receptors to gain more insight into possible target interventions for NEC.
