Recent advance in experimental animal models of anti-N-methyl-D-aspartate receptor encephalitis
10.3760/cma.j.cn113694-20210825-00586
- VernacularTitle:抗N-甲基-D-天冬氨酸受体脑炎动物模型制备的研究进展
- Author:
Yuchen LI
1
;
Fang ZHANG
;
Huijun SHEN
;
Jing WANG
;
Jie WANG
Author Information
1. 山西医科大学附属第一医院神经内科，太原 030000
- Keywords:
Anti-N-methyl-D-aspartate receptor encephalitis;
Disease models,animal;
Antibodies
- From:
Chinese Journal of Neurology
2022;55(4):379-384
- CountryChina
- Language:Chinese
-
Abstract:
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis mediated by anti-NMDAR antibody. At present, the pathogenesis of the disease is not completely clear, and reliable animal models are of great significance for the study of its pathogenesis and pathophysiological process. The authors reviewed the reports of anti-NMDAR encephalitis′s animal models in recent years, and discussed the advantages and limitations of each model, in order to provide a more suitable animal model for further research on anti-NMDAR encephalitis.
