Research progress of clinical subtypes of Parkinson′s disease
10.3760/cma.j.cn113694-20210729-00530
- VernacularTitle:帕金森病的临床亚型研究进展
- Author:
Zhenzhen CHEN
1
;
Yuhu ZHANG
Author Information
1. 广东省人民医院（广东省医学科学院）神经科，广州510080
- Keywords:
Parkinson disease;
Clinical subtype;
Motor symptoms;
Nonmotor symptoms;
Heterogeneity
- From:
Chinese Journal of Neurology
2022;55(3):248-253
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease (PD) is a widely heterogeneous disorder with a broad list of motor and nonmotor manifestations. PD varies in clinical features, dominant symptoms, and rate of progression from case to case, suggesting the existence of distinct subtypes. Research on PD subtypes aims to understand this heterogeneity. This review summarized the commonly used PD subtyping solutions and discussed the challenges and future perspectives of subtyping. In future study, by designing a more standardized research and comparing the differences of these subtypes in terms of a number of putative biomarkers, that might help to better understand the underlying disease mechanisms, predict prognosis, and eventually design more efficient personalized management strategies.
