Diagnosis and treatment of myasthenia gravis
10.3760/cma.j.cn113694-20211225-00928
- VernacularTitle:重症肌无力的诊断与治疗
- Author:
Zhuyi LI
1
;
Ting CHANG
Author Information
1. 解放军空军军医大学第二附属医院神经内科，西安710038
- Keywords:
Myasthenia gravis;
Diagnosis;
Treatment
- From:
Chinese Journal of Neurology
2022;55(3):238-247
- CountryChina
- Language:Chinese
-
Abstract:
Myasthenia gravis (MG) is mainly acetylcholine receptor antibody-mediated acquired autoimmune disease that affects the postsynaptic membrane at the neuromuscular junction. The predominant manifestation is muscle weakness. Extraocular muscles are frequently affected in the early stage of disease with typical symptoms of intermittent drooping of the upper eyelid (ptosis) and double vision (diplopia), which is easy to be misdiagnosed as an ophthalmic disease. When the weakness of the face, bulbar, neck and limb muscles occur, it needs to be differentiated from a variety of diseases. Other clinical disorders can present in a similar fashion and may be mistakenly labeled as MG. This paper summarizes the epidemiology, etiology, pathogenesis, clinical manifestations, classification, auxiliary examination, diagnosis, differential diagnosis, and treatment progress of MG, which can be used as a reference for clinicians and neurologists.
