Dynamic Contrast-Enhanced MR Imaging in Detecting Local Tumor Progression after HIFU Ablation of Localized Prostate Cancer.
10.13104/jksmrm.2013.17.3.192
- Author:
Jung Jae PARK
1
;
Chan Kyo KIM
;
Hyun Moo LEE
;
Byung Kwan PARK
;
Sung Yoon PARK
Author Information
1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. chankyokim@skku.edu
- Publication Type:Original Article
- Keywords:
High intensity focused ultrasound;
Localized prostate cancer;
Magnetic resonance imaging (MRI);
Dynamic contrast-enhanced MRI
- MeSH:
Biopsy;
Humans;
Observer Variation;
Prostate;
Prostate-Specific Antigen;
Prostatic Neoplasms;
Retrospective Studies;
Sensitivity and Specificity
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2013;17(3):192-199
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To retrospectively evaluate the diagnostic performance of dynamic contrast-enhanced MR imaging (DCE-MRI) in detecting recurrent prostate cancer after HIFU of clinically localized cancer, as compared with T2-weighted imaging (T2WI). MATERIALS AND METHODS: Twenty-six patients with increased prostate-specific antigen levels after HIFU were included in this study. All MR examinations were performed using T2WI and DCE-MRI, followed by transrectal ultrasound-guided biopsy. MRI and biopsy results were correlated in six prostate sectors. Residual or recurrent cancer after HIFU was defined as local tumor progression if biopsy results showed any cancer foci. Two independent readers interpreted the MR images. RESULTS: Of 156 prostate sectors, 51 (33%) were positive for cancer in 17 patients. For detecting local tumor progression, the sensitivity of DCE-MRI and T2WI was 80% and 57% for reader 1 (P < 0.001) versus 84% and 61% for reader 2 (P < 0.001), respectively. The specificity and overall accuracy between DCE-MRI and T2WI showed no statistical difference in both readers (P > 0.05). Interobserver agreement of DCE-MRI and T2WI was moderate and fair, respectively. CONCLUSION: For detecting local tumor progression of prostate cancer after HIFU, DCE-MRI was more sensitive than T2WI, with less interobserver variability.
