The effectiveness and safety of Morinidazole for acute complicated appendicitis undergoing laparoscopic appendectomy
10.3760/cma.j.cn113855-20201105-00844
- VernacularTitle:吗啉硝唑联合腹腔镜微创手术治疗急性非单纯性阑尾炎有效性及安全性分析
- Author:
Zhida CHEN
1
;
Hongqing XI
;
Yun TANG
Author Information
1. 解放军总医院第一医学中心普通外科医学部，北京 100853
- Keywords:
Appendicitis;
Surgical procedures,minimally invasive;
Morinidazole;
Anaerobic bacteria infection
- From:
Chinese Journal of General Surgery
2022;37(1):35-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effectiveness and safety of Morinidazole combined laparoscopic appendectomy for acute purulent appendicitis and acute gangrene appendicitis.Methods:We retrospectively retrieved 387 acute appendicitis patients who have received surgery or conservative treatment from Jan 2017 to Jun 2019. Firty four patients with Morinidazole + Etimicin bigeminy combined laparoscopic surgery were set to experimental group. The other 54 cases using ornidazole + levofloxacin bigeminy combined laparoscopic appendectomy were enrolled into control group after Propensity Score Matching.Results:After 1∶1 propensity score matching, there was no statistically significant difference between the two groups and control group in clinical features. The white blood cell count, C-reactive protein and calcitonin original inflammation index change were higher in experimental group than in the control group,both preoperatived and on post-op day1 and day 3 (all P<0.05). In the experimental group the length of hospital stay and analgesic drug usetime were shorter than in the control group (all P<0.05). Conclusion:Morinidazole combined laparoscopic appendectomy can effectively control the intra-abdominal infection caused by acute purulent appendicitis and acute gangrene appendicitis with less adverse reactions.
