Long-term quality-of-life comparison between three reconstruction methods after gastrectomy in patients with stage Ⅰ proximal gastric cancer
10.3760/cma.j.cn113855-20210617-00369
- VernacularTitle:Ⅰ期近端胃癌术后三种消化道重建方式对患者术后长期生活质量的影响
- Author:
Li HU
1
;
Rihong ZHANG
;
Xiaowei SUN
Author Information
1. 中山大学肿瘤防治中心胃外科 华南肿瘤学国家重点实验室 肿瘤医学协同创新中心，广州 510060
- Keywords:
Stomach neoplasms;
Anastomosis, surgical;
Quality of life;
Gastrectomy
- From:
Chinese Journal of General Surgery
2021;36(12):905-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of three reconstruction methods after gastrectomy on long-term quality of life in patients with stage Ⅰ proximal gastric cancer.Methods:A retrospective study was performed on 157 cases including respectively total gastrectomy with Roux-en-Y anastomosis (TG+RY group, 75 cases), 39 cases of proximal gastrectomy with esophagogastrostomy (PG+EG group) and 43 cases of proximal gastrectomy with jejunal interposition anastomosis (PG+JI group). The primary outcomes were evaluated in terms of alimentary tract symptoms, nutritional status of postoperative patients and long-term complications. Secondary outcomes pertaining to safety and long-term survival status were included as well.Results:The improvement of Visick grading in PG+JI and TG+RY group were better than that in PG+EG group ( P adj<0.01); The nutritional status of PG+JI group was better than TG+RY group and PG+EG group ( P adj<0.01); PG+JI group and PG+EG group had extra complications related to remnant stomach, but there was no significant difference in anastomotic and biliary related complications among the three groups; The incidence of reflux esophagitis in PG+JI group was significantly lower than that in PG+EG group ( P adj<0.01). There was no significant difference between the three groups in operation time, intraoperative blood loss, early postoperative complications, pathological results, 5-year cumulative survival rate and 5-year disease-free survival rate ( P>0.05). Conclusions:PG+JI improves the long-term quality of life for patients with stage Ⅰ proximal gastric cancer compared to TG+RY and PG+EG .
