Potency of remimazolam in inhibiting ventilatory function during sedation in patients undergoing internal jugular vein puncture
10.3760/cma.j.cn131073.20210215.01210
- VernacularTitle:瑞马唑仑用于颈内静脉穿刺术镇静时抑制患者通气功能的效力
- Author:
Lu LI
1
;
Xiaofei WANG
;
Wei ZHANG
;
Fanmin MENG
;
Jiaqiang ZHANG
Author Information
1. 河南省人民医院（郑州大学人民医院）麻醉与围术期医学科 450003
- Keywords:
Benzodiazepines;
Phlebotomy;
Pulmonary ventilation;
Dose-relationship, drug
- From:
Chinese Journal of Anesthesiology
2021;41(12):1451-1453
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the potency of remimazolam in inhibiting ventilatory function during sedation in the patients undergoing internal jugular vein puncture.Methods:American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients of either sex, aged 18-64 yr, with body mass index<30 kg/m 2, undergoing elective internal jugular vein puncture under local anesthesia, were enrolled in this study.Remimazolam was intravenously injected, and the dose was determined by up-and-down sequential allocation.The initial dose was 0.07 mg/kg and was increased/decreased in the next patient depending on whether the patients showed inhibition of ventilatory function, and the ratio between the 2 successive doses was 1.2.The criterion for inhibition of ventilatory function was defined as Integrated Pulmonary Index < 5.The median effective dose (ED 50) and 95% confidence interval of remimazolam in inhibiting ventilatory function were calculated by Dixon-Massey method. Results:Thirty-six patients were enrolled in this study.The ED 50 (95% confidence interval) was 0.106 (0.097-0.115) mg/kg. Conclusion:The ED 50 of remimazolam in inhibiting ventilatory function during sedation in internal jugular vein puncture is 0.106 mg/kg.
