Latest research progress on pathological mechanism of senile pruritus
10.3760/cma.j.issn.0254-9026.2022.02.023
- VernacularTitle:老年瘙痒症病理机制研究进展
- Author:
Yan CAO
1
;
Anping ZHANG
Author Information
1. 安徽医科大学第一附属医院皮肤性病科 230022
- Keywords:
Skin;
Pruritus
- From:
Chinese Journal of Geriatrics
2022;41(2):240-243
- CountryChina
- Language:Chinese
-
Abstract:
The pathological mechanism of the occurrence of elderly pruritus has not yet been fully elucidated.The changes in lipid composition between keratinocytes, incomplete structure of membrane filaggrin, decreased levels of natural moisturizing factors, changes in pH and decreased levels of estrogen can lead to impaired skin barrier function, and play an important role in the pathogenesis of skin pruritus.An inflammatory environment caused by immune aging, and neurological degenerative changes and pathological damage are also believed to influence the occurrence of senile pruritus.In addition, some systemic diseases are also closely related to the occurrence and development of pruritus in the elderly, such as chronic kidney disease, cholestatic diseases, diabetes, malignant tumors, etc.Further elucidation of the pathological mechanism of pruritus in the elderly can provide useful diagnosis and treatment ideas for the prevention and treatment of diseases.
