Research progress on the radioprotective effects of epigallocatechin gallate (EGCG) on normal tissues

VernacularTitle:表没食子儿茶素没食子酸酯正常组织辐射防护研究进展
Author: Liwei XIE ¹ ; Shang CAI ; Ming LI ; Ye TIAN
Author Information

1. 苏州大学附属第二医院放射治疗科　苏州大学放射肿瘤治疗学研究所，苏州　215004
Keywords: Eigallocatechin gallate; Radiation protection; Research progress
From: Chinese Journal of Radiation Oncology 2022;31(3):293-297
CountryChina
Language:Chinese
Abstract: Eigallocatechin gallate (EGCG) is the main component of catechins in green tea. It has many biological functions, such as neuroprotective, hypoglycemic, antioxidant, antibacterial, antiviral and anti-tumor effects, etc. It has been widely used in food additives and health products. Radiotherapy is one of the main methods for the treatment of malignant tumors. However, due to its damage to the normal tissues surrounding tumors, the therapeutic dose of radiotherapy is limited and the local control rate of tumors is affected. Therefore, it is of great practical significance to find a kind of radioprotective agent, which is highly effective and non-toxic and has the ability to limit tumor growth. This review summarizes relevant preclinical studies and clinical trial data to reveal the radiation protective mechanism of EGCG, aiming to provide some reference for EGCG to become a potential clinical radiation protection agent.