Changes of brain functional imaging in patients with major depressive disorder during different periods of antidepressant treatment
10.3760/cma.j.cn371468-2021110-00642
- VernacularTitle:抗抑郁药物不同治疗时期抑郁症患者脑功能影像的变化
- Author:
Shudong ZHANG
1
;
Yuan ZHOU
;
Zhifang ZHANG
;
Gang WANG
Author Information
1. 首都医科大学附属北京安定医院，国家精神心理疾病临床医学研究中心，精神疾病诊断与治疗北京市重点实验室，北京 100088
- Keywords:
Major depressive disorder;
Antidepressant treatment;
Neuroimaging;
Short-term treatment;
Acute treatment;
Long-term treatment
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2022;31(4):378-384
- CountryChina
- Language:Chinese
-
Abstract:
It is unclear whether antidepressants have the same effects on the brain function at different periods of treatment.In this paper, in order to improve the understanding of the neurobiological mechanisms of antidepressants from brain network level, find the target of antidepressants, optimize treatment strategy, four common neuroimaging techniques were reviewed to investigate the changes of brain functional imaging in patients with major depressive disorder at different periods (short-term, acute and long-term) after antidepressant treatment.After short-term antidepressant treatment, the changes of brain functional imaging mainly involved the amygdala, insula, prefrontal cortex, dorsal anterior cingulate cortex and so on, and these short-term changes of brain functional imaging could predict acute efficiency.After acute stage of antidepressant treatment, the changes of brain functional imaging were mostly located in the brain regions of cortical-limbic circuit and default mode network.The effect of long-term antidepressant treatment on brain functional imaging still needs to be further studied.In the future, the experimental design should be optimized and multiple neuroimaging techniques should be combined to conduct longitudinal long-term studies at multiple time points.
