Development and challenge of human lentoid bodies generation
10.3760/cma.j.cn115989-20220114-00015
- VernacularTitle:晶状体类器官培养技术的发展与挑战
- Author:
Qiuli FU
1
;
Ke YAO
Author Information
1. 浙江大学眼科医院 浙江大学医学院附属第二医院眼科中心，杭州 310009
- Keywords:
Lentoid bodies;
Lens;
Organoids;
Stem cells;
Cataract
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(5):385-388
- CountryChina
- Language:Chinese
-
Abstract:
Organoid is one of the hottest areas of research in the field of stem cells, which is an organ in a dish with three-dimensional structure and physiological functions that are highly similar to organs in vivo.At present, the generation methods of lens organoids, namely the lentoid bodies, have been established and continuously developed.The double-convex transparent lentoid bodies, with refractive function and all microscopic components of natural lenses, act as reliable in vitro models of human lenses and provide convenience for studying the mechanism of lens development.Moreover, the establishment of age-related cataract and congenital cataract models based on the lentoid bodies also provides great convenience and reliability for the study of pathological mechanism of cataract and drug screening, showing broad prospects in basic research and even clinical transformation for cataract.
