Mechanism of adrenocorticotropic hormone in the treatment of nephrotic syndrome
10.3760/cma.j.cn101070-20200810-01325
- VernacularTitle:促皮质素在肾病综合征中的作用机制
- Author:
Yi XIE
1
;
Jingjing WANG
;
Haidong FU
;
Jianhua MAO
Author Information
1. 浙江大学医学院附属儿童医院肾脏内科，杭州 310003
- Keywords:
Adrenocorticotropic hormone;
Nephrotic syndrome;
Podocyte;
Immunoregulation
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(1):74-76
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, it has been demonstrated in some studies that adrenocorticotropic hormone (ACTH) is effective in the treatment of certain steroid-resistant nephrotic syndrome, including membranous nephropathy, focal segmental glomerular sclerosis, minimal change nephropathy and so forth.ACTH can effectively relieve proteinuria and protect renal function, suggesting that there may be other mechanisms in addition to the adrenocorticotropic effect.This article mainly introduces the biological characteristics of ACTH, in combination with the clinical and basic studies on the treatment of nephrotic syndrome by ACTH, and clarifies several possible mechanisms, in an attempt to provide basis for clinical application.
