Role of adaptive immune cells in the pathogenesis of juvenile idiopathic arthritis
10.3760/cma.j.issn.1673-4408.2022.02.014
- VernacularTitle:适应性免疫细胞在幼年特发性关节炎发病机制中的作用
- Author:
Lili YE
1
;
Yanliang JIN
Author Information
1. 上海交通大学医学院附属上海儿童医学中心风湿免疫科 200127
- Keywords:
Juvenile idiopathic arthritis;
B lymphocytes;
T lymphocytes
- From:
International Journal of Pediatrics
2022;49(2):130-134
- CountryChina
- Language:Chinese
-
Abstract:
Juvenile idiopathic arthritis(JIA)is a common chronic rheumatic disease in childhood.It is not a single disease, but a group of heterogeneous diseases including different subtypes.The etiology and pathogenesis of JIA are still unclear.It is currently believed that immune response disorders play an important role in its pathogenesis and development.Different subgroups of adaptive immune cells(including T lymphocytes and B lymphocytes, etc.)may participate in the pathogenesis of different subtypes of JIA, leading to different clinical manifestations.However, the specific mechanism of action and related molecular signaling pathways have not been fully elucidated.This paper reviews the latest research results in recent years and explores the role of different types of adaptive immune cells in the development of various subtypes of JIA, which will help the precise diagnosis and individualized treatment of each subtype of JIA.
