Application of homology modeling technique in congenital cardiovascular disease
10.3760/cma.j.issn.1673-4408.2022.02.003
- VernacularTitle:同源建模技术在先天性心血管疾病机制研究中的应用
- Author:
Qi SUN
1
;
Caixia LIU
Author Information
1. 山西医科大学儿科医学系，太原 030001
- Keywords:
Congenital cardiovascular disease;
Homology modeling;
Gene mutation
- From:
International Journal of Pediatrics
2022;49(2):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Congenital cardiovascular disease is a kind of congenital disease caused by the interaction of multiple factors such as heredity, environment and pregnancy infection, but its exact etiology is still unclear.With the deepening of research, more and more evidences show that genetic factors play a significant role in its pathogenesis.Many genes are involved in the development of heart embryos, and the mutation of these genes often leads to congenital cardiovascular diseases.Homology modeling is a technique to predict the structural and functional changes of proteins caused by gene mutation through computer algorithm, and its application in the pathogenesis of congenital diseases has become a future trend.The purpose of this paper is to review homology modeling and its application in pathogenesis of congenital cardiovascular diseases briefly.
