Clinical characteristics and prognosis analysis of patients with primary systemic anaplastic large cell lymphoma
10.3760/cma.j.cn115356-20210909-00216
- VernacularTitle:原发系统型间变性大细胞淋巴瘤患者临床特征及预后分析
- Author:
Zhenxing WANG
1
;
Xiaojing XING
Author Information
1. 中国医科大学肿瘤医院 辽宁省肿瘤医院血液乳腺内科，沈阳 110042
- Keywords:
Lymphoma, large-cell, anaplastic;
Anaplastic lymphoma kinase;
Prognosis;
Antineoplastic combined chemotherapy protocols
- From:
Journal of Leukemia & Lymphoma
2022;31(5):290-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical charateristics and prognostic factors of patients with primary systemic anaplastic large cell lymphoma (ALCL).Methods:The clinicopathological data of 31 patients with newly treated primary systemic ALCL in Liaoning Cancer Hospital from January 2010 to December 2020 were retrospectively analyzed. Kaplan-Meier method was used to make survival analysis and log-rank test was performed. Multivariate analysis of factors influencing overall survival (OS) was performed by using Cox proportional hazards model.Results:Among 31 patients, there were 19 males and 12 females, with a median age of 47 years old, ranging from 16 to 74 years old. There were 18 (58.1%) patients with B symptoms, 16 (51.6%) patients with increased platelet count, 22 (71.0%) patients with Ann Arbor stage Ⅲ-Ⅳ. Until the end of follow-up, 22 cases survived and 9 cases died; the 5-year OS rate was 70.9%, and the median OS time was not reached. The 5-year OS rate of patients receiving CHOPE chemotherapy regimen was higher than that of patients receiving CHOP and other chemotherapy regimens, and the difference was statistically significant ( P = 0.049). There were statistically significant differences in the 5-year OS rates of patients with different platelet count, international prognostic index (IPI) score, chemotherapy regimens and with or without B symptoms (all P < 0.05). Multivariate analysis indicated that IPI score was an independent factor affecting OS ( HR = 2.194, 95% CI 1.078-4.465, P = 0.030). Conclusions:Most primary systemic ALCL patients are diagnosed at advanced stage and it is more common in males. Most patients have B symptoms and high platelet count. IPI score is an important prognostic factor, and CHOPE regimen may be a good choice of the first-line chemotherapy.
