Research progress of powder modification of TCM based on particle design theory
10.16438/j.0513-4870.2021-1469
- VernacularTitle:基于粒子设计原理的中药粉体改性研究进展
- Author:
Wei-feng ZHU
1
;
Fu-cai CHEN
1
;
Wen-jun LIU
2
;
Liang-shan MING
1
;
Yong-mei GUAN
1
;
Li-hua CHEN
1
;
Zhe LI
1
Author Information
1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China
2. Jiangzhong Pharmaceutical Co. Ltd., Nanchang 330049, China
- Publication Type:Research Article
- Keywords:
particle design;
powder modification based on traditional Chinese medicine;
theory of particle design;
technology for powder modification;
equipment for powder modification
- From:
Acta Pharmaceutica Sinica
2022;57(6):1781-1791
- CountryChina
- Language:Chinese
-
Abstract:
Particle design, based on the concept of "quality by design", combines the elements of microbiology, formulation science, heat and mass transfer, solid state physics, powder science, and nanotechnology. It is widely used to develop particles with excellent functional properties. Without affecting the active ingredients, the modification technology of traditional Chinese medicine (TCM) powder based on particle design theory, could improve the flowability, tabletability, disintegration and dissolution behavior, hygroscopicity, wettability, and other functional properties at the physical structure level. This greatly promotes the development of solid preparations of TCM. The present review aims to summarize and discuss the research progress of powder modification of TCM from the perspective of the theory of particle design, powder modification technology, equipment used for powder modification, application in TCM and modification mechanism mainly based on researches published in recent ten years. This review could provide ideas and theory basis for the development of particle design.
