Prognostic Value of Average Daily Platelet Increase in Childhood B-cell Acute Lymphoblastic Leukemia Patients.
10.19746/j.cnki.issn.1009-2137.2022.02.015
- Author:
Lan CHEN
1
;
Qi CHEN
1
;
Yue-Fang WANG
2
,
3
Author Information
1. Department of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, Sichuan Province, China.
2. Department of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, Sichuan Province, China,E-mail: wangyf20002005@
3. com.
- Publication Type:Journal Article
- Keywords:
B-cell acute lymphoblastic leukemia;
child;
flow cytometry;
minimal residual disease;
platelet
- MeSH:
Blood Platelets;
Burkitt Lymphoma;
Child;
Disease-Free Survival;
Humans;
Neoplasm, Residual/diagnosis*;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy*;
Prognosis;
Retrospective Studies
- From:
Journal of Experimental Hematology
2022;30(2):413-417
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the prognosis value of average daily platelet amount increase in children with B-cell acute lymphoblastic leukemia(B-ALL) treated by CCCG-ALL-2015 regimen.
METHODS:106 children with primary B-ALL were retrospective analyzed, standardized MRD test protocol was used to detect the MRD level (19 d and 46 d) after chemotherapy. The platelet count was measured by Sysmex XE-2100. Kaplan-Meier survival curve statistics was used to analyze the event free survival(EFS) rate of the children.
RESULTS:The trend of negative correlation existed between PPC and TPR (rs=-0.519, P=0.021). The 3-year EFS rate of the patients in Ap>5.4×109/L group was 95.7%, which was significantly higher than those in Ap≤5.4×109/L group(79.5%) (χ2=5.236, P=0.035); multivariate analysis showed that Ap≤5.4×109/L was the independent prognostic factor affecting survival of the patients (RR=3.978; 95%CI: 1.336-11.523, P=0.041). With both MRD and Ap≤5.4×109/L as candidate variables, Ap≤5.4×109/L lost its independent prognostic value (RR=1.225; 95%CI: 0.892-13.696, P=0.089), the correlation between d 19/d 46 MRD levels and Ap>5.4×109/L (χ2=4.318, P=0.038) could explain the phenomenon.
CONCLUSION:Ap can reflect the effect of B-ALL chemotherapy and can be used to monitor the curative effect and prognosis of B-ALL children.
