Research Advances on the Role of Bone Marrow Stromal Cell in Acute Lymphoblastic Leukemia --Review.
10.19746/j.cnki.issn.1009-2137.2022.01.053
- Author:
Jun-Nan KANG
1
;
Ze-Hui CHEN
1
;
Chen TIAN
2
Author Information
1. Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
2. Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China,E-mail: tcgirl2002@sina.com.
- Publication Type:Review
- Keywords:
acute lymphoblastic leukemia;
apoptosis;
bone marrow stromal cell;
drug resistance;
proliferation
- MeSH:
Apoptosis;
Bone Marrow;
Bone Marrow Cells;
Humans;
Mesenchymal Stem Cells;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Stromal Cells;
Tumor Microenvironment
- From:
Journal of Experimental Hematology
2022;30(1):319-322
- CountryChina
- Language:Chinese
-
Abstract:
Acute lymphoblastic leukemia (ALL) is a kind of the most common hematopoietic malignancy, its recurrence and drug resistance are closely related to the bone marrow microenvironment. Bone marrow stromal cell (BMSC) is an important part of the bone marrow microenvironment and their interaction with leukemia cells cannot be ignored. BMSC participates in and regulate signaling pathways related to proliferation or apoptosis of ALL cells by secretes cytokines or extracellular matrix proteins, thus affecting the survival of ALL cells. In this review, the research advance of several signaling pathways of the interaction between BMSC and ALL cells was summarized briefly.
