The Relationship of Adiponectin/Leptin Ratio with Homeostasis Model Assessment Insulin Resistance Index and Metabolic Syndrome in Apparently Healthy Korean Male Adults.
10.4093/kdj.2010.34.4.237
- Author:
Chan Hee JUNG
1
;
Eun Jung RHEE
;
Ji Hoon CHOI
;
Ji Cheol BAE
;
Seung Hyun YOO
;
Won Jun KIM
;
Cheol Young PARK
;
Ji Oh MOK
;
Chul Hee KIM
;
Won Young LEE
;
Ki Won OH
;
Sung Woo PARK
;
Sun Woo KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
- Publication Type:Original Article
- Keywords:
Adiponectin/leptin ratio;
Insulin resistance;
Metabolic syndrome
- MeSH:
Adiponectin;
Adipose Tissue;
Adult;
Body Mass Index;
Electric Impedance;
Enzyme-Linked Immunosorbent Assay;
Fasting;
Glucose;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Leptin;
Male;
Radioimmunoassay;
Risk Factors
- From:Korean Diabetes Journal
2010;34(4):237-243
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults. METHODS: Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed. RESULTS: Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors. CONCLUSION: A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.
