Multi-functional osteoclasts in matrix-based tissue engineering bone.
10.1016/j.cjtee.2021.11.003
- VernacularTitle:Multi-functional osteoclasts in matrix-based tissue engineering bone
- Author:
Yue-Qi CHEN
1
;
Wen-Hui HU
2
;
Zi-Cai DONG
2
;
Shi-Wu DONG
3
Author Information
1. Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
2. Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
3. Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China; Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, China; State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. Electronic address: dongshiwu@tmmu.edu.cn.
- Publication Type:Review
- Keywords:
Bone regeneration;
Matrix based-tissue engineering bone;
Micro-environment;
Osteoclasts
- MeSH:
Bone Regeneration;
Bone and Bones;
Humans;
Osteoclasts;
Tissue Engineering
- From:
Chinese Journal of Traumatology
2022;25(3):132-137
- CountryChina
- Language:English
-
Abstract:
The repair of bone defects, especially for the large segment of bone defects, has always been an urgent problem in orthopedic clinic and attracted researchers' attention. Nowadays, the application of tissue engineering bone in the repair of bone defects has become the research hotspot. With the rapid development of tissue engineering, the novel and functional scaffold materials for bone repair have emerged. In this review, we have summarized the multi-functional roles of osteoclasts in bone remodeling. The development of matrix-based tissue engineering bone has laid a theoretical foundation for further investigation about the novel bone regeneration materials which could perform high bioactivity. From the point of view on preserving pre-osteoclasts and targeting mature osteoclasts, this review introduced the novel matrix-based tissue engineering bone based on osteoclasts in the field of bone tissue engineering, which provides a potential direction for the development of novel scaffold materials for the treatment of bone defects.
