Quality markers of Zingiberis Rhizoma Carbonisata before and after processing.
10.19540/j.cnki.cjcmm.20220120.201
- Author:
Yu-Ting HUANG
1
;
Yue SUN
1
;
Jiang MENG
1
;
Shu-Mei WANG
1
Author Information
1. Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province,Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica, National Administration of Traditional Chinese Medicine(TCM), School of Traditional Chinese Medicine, Guangdong Pharmaceutical University Guangzhou 510006, China.
- Publication Type:Journal Article
- Keywords:
10-gingerol;
6-gingerol;
6-shogaol;
8-gingerol;
Zingiberis Rhizoma Carbonisata;
diacetyl-6-gingerol;
gingerone;
quality marker
- MeSH:
Biomarkers/analysis*;
Chromatography, High Pressure Liquid/methods*;
Drugs, Chinese Herbal/chemistry*;
Ginger;
Mass Spectrometry;
Plant Extracts;
Rhizome/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(7):1765-1775
- CountryChina
- Language:Chinese
-
Abstract:
Based on the previous research results of our group and literature research, the chemical components, mechanisms, pharmacodynamics, and pharmacokinetics of Zingiberis Rhizoma Carbonisata were summarized to determine the quality markers(Q-markers) of Zingiberis Rhizoma Carbonisata and Zingiberis Rhizoma. Our research group has clarified the differential components of Zingiberis Rhizoma Carbonisata and Zingiberis Rhizoma, the meridian-warming hemostatic effect of Zingiberis Rhizoma Carbonisata, the related targets and pathways of the effect, the endogenous biomarkers of Zingiberis Rhizoma Carbonisata, and the hemodynamic processes of Zingiberis Rhizoma Carbonisata and Zingiberis Rhizoma. Moreover, based on high-performance liquid chromatography-diode array detector-electrospray ionization mass spectrometry(HPLC-DAD-ESIMS), a method for determining the content of Q-mar-kers was established. In conclusion, the study finally determined that gingerone, 6-shogaol, and diacetyl-6-gingerol were the Q-mar-kers of Zingiberis Rhizoma Carbonisata decoction pieces, and 6-gingerol, 8-gingerol, and 10-gingerol were Q-markers of Zingiberis Rhizoma decoction pieces. The result is expected to provide a reference for the establishment of quality standards for Zingiberis Rhizoma Carbonisata decoction pieces and Zingiberis Rhizoma decoction pieces.
