Efficacy-related substances of blood-activating and stasis-resolving medicinals derived from Curcuma plants: a review.
10.19540/j.cnki.cjcmm.20210817.603
- Author:
Yu-Wen QIN
1
;
Cheng-Hao FEI
1
;
Wei ZHANG
2
;
Yu LI
1
;
Zhen XU
1
;
Lian-Lin SU
1
;
De JI
1
;
Chun-Qin MAO
1
;
Tu-Lin LU
1
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
- Publication Type:Review
- Keywords:
Curcumae Longae Rhizoma;
Curcumae Radix;
Curcumae Rhizoma;
Wenyujin Rhizoma Concisum;
activating blood and resolving stasis;
efficacy-related substances
- MeSH:
Curcuma;
Curcumin;
Drugs, Chinese Herbal;
Plant Roots;
Platelet Aggregation;
Rhizome
- From:
China Journal of Chinese Materia Medica
2022;47(1):24-35
- CountryChina
- Language:Chinese
-
Abstract:
Derived from Curcuma plants, Curcumae Longae Rhizoma, Curcumae Rhizoma, Wenyujin Rhizoma Concisum, and Curcumae Radix are common blood-activating and stasis-resolving medicinals in clinical practice, which are mainly used to treat amenorrhea, dysmenorrhea, chest impediment and heart pain, and rheumatic arthralgia caused by blood stasis block. According to modern research, the typical components in medicinals derived from Curcuma plants, like curcumin, demethoxycurcumin, bisdemethoxycurcumin, curdione, germacrone, curcumol, and β-elemene, have the activities of hemorheology improvement, anti-platelet aggregation, anti-thrombosis, anti-inflammation, anti-tumor, and anti-fibrosis, thereby activating blood and resolving stasis. However, due to the difference in origin, medicinal part, processing, and other aspects, the efficacy and clinical application are different. The efficacy-related substances behind the difference have not yet been systematically studied. Thus, focusing on the efficacy-related substances, this study reviewed the background, efficacy and clinical application, efficacy-related substances, and "prediction-identification-verification" research method of blood-activating and stasis-resolving medicinals derived from Curcuma plants, which is expected to lay a theoretical basis for the future research on the "similarities and differences" of such medicinals based on integrated evidence chain and to guide the scientific and rational application of them in clinical practice.
