Effect of acupuncture on pregnancy outcomes of frozen embryo transfer in patients with anovulatory infertility.
10.13703/j.0255-2930.20210206-0002
- Author:
Lin-Ling XU
1
;
Xue ZHOU
2
;
Cai-Rong ZHANG
1
;
Jian-Bin ZHANG
3
Author Information
1. Department of Acupuncture and Moxibustion, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210001, Jiangsu Province, China.
2. Reproductive Center, Nanjing Maternity and Child Health Care Hospital.
3. Department of Acupuncture and Moxibustion, Second Affiliated Hospital of Nanjing University of Chinese Medicine/Second Chinese Medicine Hospital of Jiangsu Province, Nanjing
- Publication Type:Randomized Controlled Trial
- Keywords:
acupuncture;
anovulatory infertility;
endometrial receptivity;
frozen embryo transfer;
pregnancy outcomes
- MeSH:
Acupuncture Therapy;
Embryo Transfer;
Female;
Humans;
Infertility, Female/therapy*;
Pregnancy;
Pregnancy Outcome;
Pregnancy Rate
- From:
Chinese Acupuncture & Moxibustion
2022;42(2):150-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of conventional ovulation induction protocol and acupuncture combined with conventional ovulation induction protocol on pregnancy outcomes of frozen embryo transfer (FET) in patients with anovulatory infertility.
METHODS:A total of 60 patients with anovulatory infertility were randomized into an observation group and a control group, 30 cases in each group. In the control group, conventional ovulation induction protocol was applied to prepare endometrium. On the basis of the control group, acupuncture was started on the 2nd day of menstrual cycle in the observation group，Baihui (GV 20), Mingmen (GV 4), Geshu (BL 17), Guanyuan (CV 4), Qihai (CV 6), etc. were selected, once every other day, until 1 day before transplantation. The clinical pregnancy rate, embryo implantation rate, endometrial morphology on HCG trigger day, ovulation rate and cycle cancellation rate were compared in the two groups. The endometrial thickness before treatment and on HCG trigger day, TCM symptom score before and after treatment were observed in the two groups.
RESULTS:In the observation group, the embryo implantation rate and clinical pregnancy rate were higher than the control group (P<0.05), endometrial thickness and endometrial morphology on HCG trigger day were superior to the control group (P<0.05). After treatment, the TCM symptom score in the observation group was decreased compared with before treatment (P<0.05), and the variation was greater than the control group (P<0.01).
CONCLUSION:On the basis of the conventional ovulation induction protocol, acupuncture could enhance the embryo implantation rate and clinical pregnancy rate of FET, improve the endometrial receptivity of patients with anovulatory infertility.
