The Long Search for Pharmacologically Useful Anti-Inflammatory Flavonoids and Their Action Mechanisms: Past, Present, and Future
10.4062/biomolther.2022.004
- Author:
Hyun Pyo KIM
1
Author Information
1. College of Pharmacy, Kangwon National University, Chunchon 24341, Republic of Korea
- Publication Type:Invited Review
- From:Biomolecules & Therapeutics
2022;30(2):117-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
Flavonoids are known to exert anti-inflammatory effects. Their pharmacological activities have been proved using various in vitro and in vivo models. Although their action spectrum and potencies are not adequate to alleviate acute inflammatory disorders, they have the potential to treat chronic inflammatory diseases. Recent investigations have revealed that inflammatory processes are involved in many disease processes and conditions. Some examples are skin disorders, cartilage diseases, metabolic inflammatory diseases, and aging. The effects of flavonoids on these disorders have been examined. Several possible application areas for flavonoids have been studied. Local treatment of these disorders with flavonoids is favorable to avoid systemic transformation. In this review, the findings based on the experimental results from my laboratory are summarized and the future possibility of using flavonoids clinically is discussed.`
