Recent progress on dissolution and absorption of amorphous solid dispersions
10.16438/j.0513-4870.2021-1826
- VernacularTitle:无定形固体分散体的溶出与吸收研究进展
- Author:
Hao-min WU
1
;
Jie ZHANG
1
;
Min-qian LUO
1
;
Ting CAI
2
Author Information
1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
amorphous solid dispersion;
poorly soluble drug;
crystallization;
italic>in vitro dissolution;
italic>in vivo absorption
- From:
Acta Pharmaceutica Sinica
2022;57(5):1312-1321
- CountryChina
- Language:Chinese
-
Abstract:
The amorphous solid dispersion is one of the most effective formulation approaches to enhance the oral bioavailability of poorly water-soluble drugs. However, the amorphous drugs tend to crystallize during storage or dissolution due to inadequate formulations, preparation techniques, storage and dissolution conditions, thus negating their advantages. Meanwhile, it is often difficult to establish in vitro-in vivo correlation for amorphous solid dispersions owing to the difference between dissolution media and physiological environments and between the apparent concentration and membrane transport flux, the dynamic process of the in vivo absorption, which put great challenges to the development of amorphous solid dispersion products. This review covers the recent progress on the mechanistic study of the in vitro dissolution and in vivo absorption of amorphous solid dispersions, aiming to provide guidance for the formulation development of poorly soluble drugs.
