Effect of Electroacupuncture on Expression of Phosphodiesterase 4 and Subtypes in Hippocampus in Rats with Chronic Stress Depression
10.3969/j.issn.1006-9771.2016.09.005.
- VernacularTitle:电针对慢性应激抑郁模型大鼠海马磷酸二酯酶4及其亚型表达的影响①
- Author:
Quankai JING
1
;
Chaoketu SAIYIN
2
;
Haijiang YAO
3
,
4
;
Wei LV
1
;
Youdou AOCUN
1
;
Lijuan YANG
1
;
Juntong LIU
1
;
Zhigang LI
1
Author Information
1. Department of Acupuncture and Massage, Beijing University of Chinese Medicine, Beijing 100029, China;
2. Inner Mongolia International Mongolian Hospital Traditional Therapy Technique, Hohhot, Inner Mongolia 010065, China;
3. Treatment Center of Traditional Chinese Medicine, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China;
4. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
- Publication Type:Journal Article
- Keywords:
depression, electroacupuncture, chronic stress, phosphodiesterase 4, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(9):1011-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the biological mechanisms of electroacupuncture (EA) for depression. Methods Forty male adult Sprague-Dawley rats were randomly divided into control group (n=8), model group (n=8), EA group (n=8) and fluoxetine group (n=8). Depressive models were established with lonely raising and chronic unpredictable mild stress. They were tested with Open-field Test, and the expression of phosphodiesterase 4 (PDE4)A and PDE4D in hippocampus was detected with RT-PCR. Results The cross and rear scores were significantly lower in the model group than in the control group (P<0.001), while it increased in the EA group and the fluoxetine group (P<0.001). Compared with the model group, the expression of PDE4A and PDE4D decreased in the EA group (P<0.001). Conclusion Electroacupuncture may relieve depression through inhibiting the expression of PDE4A and PDE4D.
