Advance in Pathogenesis of Amyotrophic Lateral Sclerosis (review)
10.3969/j.issn.1006-9771.2017.06.014
- VernacularTitle:肌萎缩侧索硬化发病机制的研究进展
- Author:
Yongqiang GUO
1
,
2
;
Sen LI
1
;
Haihong ZHANG
2
;
Yamin WU
1
Author Information
1. State Key Laboratory of Trauma, Burns and Combined Injury, the Third Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China;
2. Department of Orthopedics, Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China
- Publication Type:Journal Article
- Keywords:
amyotrophic lateral sclerosis, pathogenesis mechanism, gene mutation, oxidative stress, excitotoxicity, mitochondrial dysfunction, immune and inflammatory, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2017;23(6):685-689
- CountryChina
- Language:Chinese
-
Abstract:
Amyotrophic lateral sclerosis (ALS), including the familial and the sporadic, accounts for the most proportion of motor neuron disease. The pathogenesis of ALS covers gene mutation, oxidative stress, excitotoxicity, mitochondrial dysfunction, immune and inflammatory, and so on. With interplay and interrelation, these mechanisms, finally, caused multisystem lesion especially motor neural system.
