The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones
10.3969/j.issn.1001-5256.2022.04.042
- VernacularTitle:肠道菌群及其代谢物在胆囊胆固醇结石形成中的作用机制
- Author:
Handong ZHAO
1
;
Peng GAO
2
;
Li ZHAN
3
Author Information
1. The First Clinical Medical College of Gansu University of Chinese Medicine & Gansu Provincial Hospital, Lanzhou 730000, China
2. Department of General Surgery, Gansu Provincial People's Hospital, Lanzhou 730000, China
3. Department of Gastroenterology, Gansu Provincial People's Hospital, Lanzhou 730000, China
- Publication Type:Reviews
- Keywords:
Gastrointestinal Microbiome;
Cholelithiasis;
Enterohepatic Circulation;
Bile Acid
- From:
Journal of Clinical Hepatology
2022;38(4):947-950
- CountryChina
- Language:Chinese
-
Abstract:
Gallstone is a common digestive system disease involving multiple factors, more than 80% of which are cholesterol gallstones, and its incidence rate is increasing year by year. Recent studies have shown that intestinal flora is involved in the development and progression of cholesterol gallstones. This article elaborates on the role of intestinal flora and its metabolites in the progression of cholesterol gallstones from the aspect of regulation of bile acids by intestinal flora and its metabolites, and it is pointed out that intervention strategies for intestinal flora and its metabolites may be a new target for the prevention and treatment of cholesterol gallstones in the future.
