Mechanism of intestinal flora imbalance in the development and progression of liver cancer and the role of probiotics in preventing liver cancer
10.3969/j.issn.1001-5256.2022.03.042
- VernacularTitle:肠道菌群失衡在肝癌发生发展中的影响机制及益生菌对肝癌的预防作用
- Author:
Yanying GAO
1
;
Huiling XIANG
1
;
Jing LIANG
1
;
Tao HAN
1
;
Xu ZHANG
1
Author Information
1. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300170, China
- Publication Type:Reviews
- Keywords:
Liver Neoplasms;
Gastrointestinal Microbiome;
Lactobacillus rhamnosus
- From:
Journal of Clinical Hepatology
2022;38(3):699-702
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal flora imbalance plays a certain role in the development and progression of liver cancer, while probiotics have a certain impact on liver cancer, both of which are the focus of clinical research. This article introduces the mechanism of action of intestinal flora imbalance in the pathogenesis of liver cancer and the preventive effect of probiotics against liver cancer. Intestinal flora imbalance can participate in the pathological process of liver cancer by activating Toll-like receptor 4, regulating the level of metabolites, producing endotoxin, and inducing bacterial translocation and intestinal bacterial overgrowth, while probiotics can effectively prevent liver cancer by maintaining enterohepatic circulation, enhancing immune function, promoting the reproduction of intestinal probiotics, and reducing the toxicity of carcinogens, which can be further studied as the focus of subsequent liver cancer prevention in clinical practice.
