Effect of high-fat diet for rats at different stages on glucose and lipid metabolism in offspring and related mechanisms.
10.7499/j.issn.1008-8830.2107121
- Author:
Ming WEI
1
;
Di ZHAN
1
;
Zhu-Xi LI
1
;
Huan-Yu WANG
1
;
Ying XING
1
;
Xiao-Ping LUO
1
Author Information
1. Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- Keywords:
Glucose and lipid metabolism;
High-fat diet;
Obesity in pregnancy;
Offspring;
Rat
- MeSH:
Animals;
Body Weight;
Diet, High-Fat/adverse effects*;
Female;
Glucose/metabolism*;
Insulin;
Insulin Resistance;
Lipid Metabolism;
Liver/metabolism*;
Male;
Pregnancy;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(11):1174-1183
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the effect of high-fat diet for maternal Sprague-Dawley rats at different stages on glucose and lipid metabolism in offspring and related mechanisms.
METHODS:According to the diet before pregnancy and during pregnancy and lactation, maternal rats were randomly divided into four groups (
RESULTS:Compared with the control diet groups (CC and CH groups), the groups with high-fat diet before pregnancy (HC and HH groups) had a significant increase in body weight (
CONCLUSIONS:High-fat diet for rats at different stages before and after pregnancy has different effects on glucose and lipid metabolism of offspring rats, and high-fat diet before pregnancy and during pregnancy and lactation has the greatest effect. The effect of high-fat diet on glucose and lipid metabolism of offspring rats is considered associated with the changes in the expression of genes involved in glucose and lipid metabolism.
