Current opinions on the mechanism, classification, imaging diagnosis and treatment of post-traumatic osteomyelitis.
10.1016/j.cjtee.2021.07.006
- VernacularTitle:Current opinions on the mechanism, classification, imaging diagnosis and treatment of post-traumatic osteomyelitis
- Author:
Jian YANG
1
;
Jiang-Ling YAO
2
;
Zi-Quan WU
1
;
De-Lu ZENG
1
;
Lin-Yang ZHENG
1
;
Dong CHEN
1
;
Zheng-Dong GUO
1
;
Lei PENG
3
,
4
Author Information
1. Trauma Center, the First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570100, China; Key Laboratory of Emergency and Trauma, Ministry of Education, Hainan Medical Univeristy, Haikou, 571199, China.
2. Trauma Center, the First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570100, China; Key Laboratory of Emergency and Trauma, Ministry of Education, Hainan Medical Univeristy, Haikou, 571199, China; Hainan Provincial Key Laboratory, Hainan Medical University, Haikou, 571199, China.
3. Trauma Center, the First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570100, China; Key Laboratory of Emergency and Trauma, Ministry of Education, Hainan Medical Univeristy, Haikou, 571199, China; Hainan Provincial Key Laboratory, Hainan Medical University, Haikou, 571199, China; Hainan Provincial Biomaterials and Medical Device Engineering Technology Research Center, Hainan Medical University, Haikou, 571199, China. Electronic address: xiaobo197518@
4. com.
- Publication Type:Review
- Keywords:
Bone infection;
Clinical classification;
Diagnosis;
Osteomyelitis;
Pathology;
Post-traumatic osteomyelitis;
Treatment
- MeSH:
Anti-Bacterial Agents/therapeutic use*;
Fractures, Bone/diagnostic imaging*;
Humans;
Osteomyelitis/therapy*
- From:
Chinese Journal of Traumatology
2021;24(6):320-327
- CountryChina
- Language:English
-
Abstract:
Post-traumatic osteomyelitis (PTO) is a worldwide problem in the field of orthopaedic trauma. So far, there is no ideal treatment or consensus-based gold standard for its management. This paper reviews the representative literature focusing on PTO, mainly from the following four aspects: (1) the pathophysiological mechanism of PTO and the interaction mechanism between bacteria and the body, including fracture stress, different components of internal fixation devices, immune response, occurrence and development mechanisms of inflammation in PTO, as well as the occurrence and development mechanisms of PTO in skeletal system; (2) clinical classification, mainly the etiological classification, histological classification, anatomical classification and the newly proposed new classifications (a brief analysis of their scope and limitations); (3) imaging diagnosis, including non-invasive examination and invasive examination (this paper discusses their advantages and disadvantages respectively, and briefly compares the sensitivity and effectiveness of the current examinations); and (4) strategies, including antibiotic administration, surgical choices and other treatment programs. Based on the above-mentioned four aspects, we try to put forward some noteworthy sections, in order to make the existing opinions more specific.
