Sample size estimation in acupuncture and moxibustion clinical trials.
10.13703/j.0255-2930.20201020-0002
- Author:
Jing HU
1
;
Bo LI
1
;
Hui-Na ZHANG
1
;
Wei-Hong LIU
1
;
Shuo FENG
1
Author Information
1. Evidence-Based Medicine Center, Beijing Hospital of TCM, Capital Medical University, Beijing Institute of TCM, Beijing 100010, China.
- Publication Type:Journal Article
- Keywords:
acupuncture and moxibustion;
equivalence trial;
non-inferiority trial;
sample size estimation;
superiority trial
- MeSH:
Acupuncture;
Acupuncture Therapy;
Clinical Trials as Topic;
Moxibustion;
Sample Size
- From:
Chinese Acupuncture & Moxibustion
2021;41(10):1147-1152
- CountryChina
- Language:Chinese
-
Abstract:
The appropriate sample size estimation is very important in the design of clinical trials. However, insufficient or inappropriate sample size estimation is still a prominent problem in the currently published acupuncture and moxibustion clinical trials. At present, the superiority test, non-inferiority test and equivalence test have been widely used in acupuncture and moxibustion clinical trials. This article focuses on the application, calculation methods and PASS11 software using of these three hypothesis test types. In view of the problems in the estimation of sample size in acupuncture and moxibustion clinical trials, the particularity of sample size estimation in acupuncture and moxibustion is summarized from the aspects of parameter setting, ratio of intervention group and control group, and multi-group comparison, in order to guide acupuncture clinical researchers to correctly estimate sample size when conducting clinical trials.
