Diagnostic criteria and research progress on pancreas allograft pathology
10.3969/j.issn.1674-7445.2022.02.005
- VernacularTitle:移植胰腺病理学诊断标准及其进展
- Author:
Hui GUO
1
;
Changsheng MING
;
Shi CHEN
Author Information
1. Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Simultaneous pancreas-kidney transplantation (SPK);
Pancreas transplantation after kidney transplantation (PAK);
Pancreas transplantation alone (PTA);
Antibody-mediated rejection (AMR);
T cell-mediated rejection (TCMR);
Donor specific antibody (DSA);
Chronic transplant arteriopathy (CTA);
Posttransplant lymphoproliferative disease (PTLD)
- From:
Organ Transplantation
2022;13(2):176-
- CountryChina
- Language:Chinese
-
Abstract:
Pancreas transplantation and pancreas-kidney transplantation are the optimal treatment for renal failure caused by type 1 diabetes mellitus, partial type 2 diabetes mellitus and their complications. Pancreas transplantation mainly includes simultaneous pancreas-kidney transplantation (SPK), pancreas transplantation after kidney transplantation (PAK) and pancreas transplantation alone (PTA). Among all types of pancreas transplantation, biopsy of pancreas allograft remains the best method for definitively diagnosing rejection and differentiate it from other complications. In this article, biopsy methods of pancreas allograft and related research progress, diagnostic criteria and research progress on rejection of pancreas allograft biopsy, and main complications and pathological manifestations of pancreas allograft were illustrated, aiming to provide reference for guiding the clinical diagnosis of the above mentioned complications and ensuring the long-term survival of pancreas allografts and recipients.
