Research Progress in Computational Simulation of Thrombosis
10.16156/j.1004-7220.2022.01.30
- VernacularTitle:计算模拟血栓形成研究进展
- Author:
Hongshuai CAO
1
;
Changyan LIN
1
Author Information
1. Beijing Institute of Heart Lung and Vascular Disease, Beijing Anzhen Hospital, Capital Medical University; Beijing Key Laboratory of Applied Basic Research of Clinical Biomechanics, Capital Medical University
- Publication Type:Journal Article
- Keywords:
thrombus;
computational simulation;
mathematical model;
finite element analysis
- From:
Journal of Medical Biomechanics
2022;37(1):E192-E196
- CountryChina
- Language:Chinese
-
Abstract:
Thrombosis is the process of platelet adhesion and aggregation or blood coagulation after the body is subjected to certain physical and chemical stimuli. At present, the use of basic experimental research and computational simulation to understand thrombosis has become a research hotspot. The complex process of thrombosis makes computational modeling very difficult, but the development of calculation models has still made great progress. At present, a variety of calculation models for thrombosis have been developed, including coagulation models based on ordinary differential equations, mathematical models based on finite element analysis, Lattice-Boltzmann method models, smooth particle dynamics method models, etc. Each model has its advantages and disadvantages.In this review, the physiological mechanism of thrombosis was explained, the models for simulating thrombosis were also systematically sorted out and evaluated, and the limitations of computational simulation and future application prospects were summarized as well.
