Strategies of microspheres and in situ forming gel implants in long-acting and research progress in controlling burst release
10.11665/j.issn.1000-5048.20220102
- VernacularTitle:微球与原位凝胶植入剂长效策略与控制突释的研究进展
- Author:
Limeng XIAO
1
;
Zhen YAN
;
Lifang YIN
Author Information
1. 中国药科大学药学院药剂系
- Publication Type:Journal Article
- Keywords:
microspheres;
in situ forming gel implant;
long-acting;
burst release;
advances
- From:
Journal of China Pharmaceutical University
2022;53(1):10-17
- CountryChina
- Language:Chinese
-
Abstract:
Long-acting injectables(LAIs) play an important role in the field of drug preparation research because they can control drug release for a long time and decrease dosing frequency. In this review, two types of LAIs, including injectable microspheres and in situ forming gel implants, were used as the breakthrough point to analyze the strategies and technologies used in the formulation and process to achieve long-acting drug release.At the same time, in view of the common burst release phenomenon, the relevant coping strategies in the current research were summarized, which provides some reference for the design, development and optimization of such long-acting preparations.
