Strategies for targeting and remodeling tumor microenvironment
10.16438/j.0513-4870.2021-1232
- VernacularTitle:肿瘤微环境的靶向和重塑策略
- Author:
Meng-meng YANG
1
;
Xiao-peng HAN
1
;
Chao QIN
1
;
Lei YANG
1
;
Li-fang YIN
1
Author Information
1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Province Engineering Research Center for R&D and Evaluation of Intelligent Drugs and Key Functional Excipients, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
tumor microenvironment;
hypoxia;
tumor associated fibroblast;
extracellular matrix;
tumor associated macrophage
- From:
Acta Pharmaceutica Sinica
2022;57(1):98-108
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment (TME) is composed of abnormal tumor vasculature, extracellular matrix components, endothelial cells, pericytes, tumor associated fibroblasts, smooth muscle cells and immune cells, which is characterized by hypoxia, acidosis and high interstitial fluid pressure. Hypoxia and acidosis within the TME trigger an adjustment of the extracellular matrix (ECM), a response from neighbor stromal cells (e.g., fibroblasts) and immune cells (lymphocytes and macrophages), inducing tumor growth, angiogenesis, and ultimately, resulting in metastasis. What's more, the components of TME including abnormal tumor vasculature, rich composition of the ECM, and abundant stroma cells impair tumoral distribution and penetration of the drugs. At the same time, this stromal microenvironment plays a vital role in creating an immunosuppressive environment.Over the past years, more and more researches focus on targeting and remolding TME to improve therapeutic effects against tumors. Herein, we reviewed current strategies developed to target and remodel TME, including modulating tumor hypoxia, tumor vasculature, tumor associated fibroblasts, extracellular matrix components, tumor associated macrophage phenotypes and dendritic cells. Also, potential problems and future directions are pointed out in this review.
