Recent advances of cell membrane-derived biomimetic nanotechnology in cancer targeted drug delivery system
10.16438/j.0513-4870.2021-1231
- VernacularTitle:细胞膜仿生纳米技术在肿瘤靶向递药系统中的研究进展
- Author:
Ling-ling HUANG
1
;
Hong-hui WU
2
;
Dong-hang XU
1
;
Jian-qing GAO
2
Author Information
1. Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
2. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
- Publication Type:Research Article
- Keywords:
cell membrane;
nanotechnology;
rug delivery system;
antitumor;
targeted therapy
- From:
Acta Pharmaceutica Sinica
2022;57(1):85-97
- CountryChina
- Language:Chinese
-
Abstract:
The development of nanotechnology has made it possible to develop safe, efficient, precise and controllable drug delivery system (DDS). Among them, organic or inorganic synthetic nanocarriers have been widely reported and used for the delivery of tumor therapeutic agents. However, some of carriers have several problems, such as easily eliminated by the body's immune system, difficult to preparation or poor safety in vivo. In recent years, with the development of biomedicine, biomimetic technology based biomembrane-mediated nanodrug delivery has organically integrated the low immunogenicity of natural biomembrane, cancer targeting, and the controllable and multifunctional of smart nanocarrier design. It will achieve a new breakthrough of nanotechnology in cancer targeted therapy. Based on the recent advances of cell membrane-derived biomimetic nanotechnology and the nanomedicine in the field of cancer therapy, this review discusses the three aspects including the experimental basis of cell membrane-derived biomimetic nanotechnology, the classification of biomimetic nanodrug delivery platforms, and the application in cancer targeted therapy. Therefore, the review will provide reference for the design of smart drug delivery system and its development in cancer targeted treatment.
