Research advances in the mechanism of action of TRPV4 ion channel protein in liver diseases
10.3969/j.issn.1001-5256.2022.01.040
- VernacularTitle:瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制
- Author:
Laying ZHANG
1
;
Mingkai CHEN
1
Author Information
1. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Reviews
- Keywords:
Liver Diseases;
Transient Receptor Potential Vanilloid 4;
Transient Receptor Potential Channels
- From:
Journal of Clinical Hepatology
2022;38(1):224-227
- CountryChina
- Language:Chinese
-
Abstract:
As a member of the transient receptor potential ion channel family, transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel and is widely distributed in a variety of tissues and organs. In recent years, more and more studies have shown that TRPV4 channel proteins are closely associated with liver diseases such as liver fibrosis, liver cancer, and polycystic liver disease. This article analyzes the articles on TRPV4 and liver disease and summarizes the exact signaling pathways and possible potential mechanism between TRPV4 and liver disease, so as to provide new ideas for clinical application and further studies.
