Progress of RNA N6-methyladenosine modification in malignant tumors of digestive system
10.3760/cma.j.cn115355-20200812-00451
- VernacularTitle:RNA N6甲基化转换酶修饰在消化系统恶性肿瘤中的研究进展
- Author:
Guoqing GU
1
;
Yixuan WEN
;
Xiaodong JIANG
Author Information
1. 徐州医科大学附属连云港医院肿瘤科，江苏 连云港 222002
- Keywords:
Digestive system neoplasms;
Molecular biology;
tRNA methyltransferases;
m6A modification
- From:
Cancer Research and Clinic
2021;33(8):627-630
- CountryChina
- Language:Chinese
-
Abstract:
RNA N6-methyladenosine (m6A) modification is an important gene expression regulation mechanism of eukaryotes. The m6A modification mainly mediates the methylation of adenosine N6. It is a reversible epigenetic modification that not only occurs in messenger RNA (mRNA), but also occurs in non-coding RNA (ncRNA). In addition, RNA m6A modification participates in many physiological and pathological processes, and also plays an important role in the occurrence and development of tumors. This article reviews the role of RNA m6A modification in malignant tumors of the digestive system.
