Role of oxidized low density lipoprotein in the diagnosis of atherosclerotic cardiovascular disease
10.3760/cma.j.cn114452-20210409-00222
- VernacularTitle:氧化低密度脂蛋白在动脉粥样硬化性心血管疾病诊断中的作用
- Author:
Xin YANG
1
;
Yanwei HU
Author Information
1. 广州市妇女儿童医疗中心检验科，广州 510000
- Keywords:
Atherosclerosis;
Oxidized low-density lipoprotein;
Cardiovascular diseases;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2021;44(7):563-568
- CountryChina
- Language:Chinese
-
Abstract:
As a critical factor of atherosclerosis (AS), oxidized low-density lipoprotein (oxLDL) plays a crucial role in damaging vascular endothelial cells, promoting monocyte adhesion, inducing formation of foam cells and thrombosis. Many scholars have found that oxLDL could be used as a circulating biomarker for atherosclerotic cardiovascular disease. In this manuscript, research progress on the mechanism of oxLDL in the initiation and development of atherosclerosis, as well as using oxLDL as a diagnostic biomarker of atherosclerosis related diseases were systemically reviewed.
