Research progress of miRNA in age-related macular degeneration
10.3760/cma.j.cn511434-20200312-00109
- VernacularTitle:miRNA在老年性黄斑变性发病机制中的作用研究进展
- Author:
Jingfan GAO
1
;
Lu ZHANG
Author Information
1. 哈尔滨医科大学附属第一医院眼科医院 150001
- Keywords:
Macular degeneration;
MicroRNAs;
Oxidative stress;
Neovascularization, pathologic;
Inflammation;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2021;37(6):488-491
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD) is a multifactorial disease affected by environmental factors and genetic variation, which is a major cause of irreversible vision loss in the elderly. miRNA is a kind of endogenous non-coding RNA, which plays an important role in the pathogenesis of AMD, such as oxidative stress, pathological neovascularization and inflammation, by inhibiting or silencing the expression of transcription genes. miRNA has unique advantages in terms of ease synthesis, targeting and additive effect, a large number of experiments have proved the therapeutic potential of miRNA in AMD, which is expected to become a new method for the treatment of AMD in the future. Since the pathogenesis of AMD has not been fully elucidated, it is still necessary to continue to study the pathogenesis of AMD, the biological effects and mechanisms of various miRNA in the occurrence and development of AMD, and observe its therapeutic effects in AMD, so as to provide more effective options for the precise prevention and treatment of AMD.
