High-dose glucocorticoid pulse therapy and dosage reduction regimen in acute attack of neuroimmune diseases
10.3760/cma.j.cn113694-20210108-00020
- VernacularTitle:重视常见神经免疫疾病激素冲击治疗和减量方案的规范性
- Author:
Jiaxin CHEN
1
;
Huiyu FENG
Author Information
1. 中山大学附属第一医院神经科，广东省重大神经疾病诊治研究重点实验室，广州510080
- Keywords:
Glucocorticoid;
Pulse therapy;
Nervous system;
Autoimmune diseases
- From:
Chinese Journal of Neurology
2021;54(9):876-884
- CountryChina
- Language:Chinese
-
Abstract:
Glucocorticoid pulse therapy is an important means to induce remission of neuroimmune diseases in acute attack stage. However, the specific programs of glucocorticoid pulse therapy in domestic hospitals are not standardized and unified at present. Here, glucocorticoid pulse therapy in acute attack of neuroimmune diseases in national and international guidelines in last decade are reviewed and summarized. Glucocorticoid pulse therapy follows the principle of large dosage and short course of treatment, and intravenous methylprednisolone 1 000 mg/d for three days to five days is the most common regimen. According to the characteristics of diseases, the dosage reduction regimens are different. Standardized glucocorticoid pulse therapy can not only maximize its curative effects, but also minimize its side effects, which deserves the attention of clinicians.
