Incidence, risk factors and prognosis of acute kidney injury early after lung transplantation
10.3760/cma.j.cn421203-20200803-00272
- VernacularTitle:肺移植术后早期急性肾损伤的发生率和危险因素及预后分析
- Author:
Lei JING
1
;
Li ZHAO
;
Lijuan GUO
;
Chaoyang LIANG
;
Jingyu CHEN
Author Information
1. 中日友好医院肺移植科 中日友好医院呼吸中心 国家呼吸临床研究中心，北京 100029
- Keywords:
Lung transplantation;
Acute kidney injury;
Risk factors
- From:
Chinese Journal of Organ Transplantation
2021;42(10):599-603
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the incidence, risk factors and outcome of acute kidney injury (AKI) early after lung transplantation (LT).Methods:Clinical data were retrospectively reviewed for 167 LT patients. AKI was defined according to the criteria of Kidney Disease Improving Global Outcomes (KDIGO) guideline within the first 7 days post-LT. AKI incidence was calculated. Multivariate analysis was performed to identify independent risk factors. Survival analysis was presented with the Kaplan-Meier curve.Results:The incidence of AKI early post-LT was 65.9%. Gender (male), preoperative higher serum creatinine (sCr), lower glomerular filtration rate (eGFR), extracorporeal membrane oxygenation (ECMO), mechanical ventilation (MV), intraoperative or postoperative hypotension, cardiovascular events, postoperative septic shock, multiple organ failure, ECMO support ≥2 days and reintubation were risk factors for AKI early post-LT ( P<0.05). Postoperative AKI was correlated with prolonged MV and/or ECMO as well as ICU stay and higher short/long-term mortality post-LT. Conclusions:The incidence of AKI early post-LT is high and affects the prognosis of LT patients. Greater attention should be paid to early prevention of AKI to reduce its incidence and improve its prognosis.
