The application of organoid models in diabetes research
10.3760/cma.j.cn311282-20210307-00146
- VernacularTitle:类器官模型在糖尿病研究领域的应用
- Author:
Jiaoyue ZHANG
1
;
Lulu CHEN
;
Qiao ZHOU
;
Tianshu ZENG
Author Information
1. 华中科技大学同济医学院附属协和医院内分泌科，武汉 430022
- Keywords:
Diabetes;
Organoid;
Stem cell;
β cell;
Microvascular complication
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(7):657-661
- CountryChina
- Language:Chinese
-
Abstract:
Organoids are complex tiny organ-like model systems formed by three-dimensional culture in vitro, based on the self-renew and self-organization of stem cells. This article reviewed the recent progress in organoids construction from tissues involved in the regulation of glucose homeostasis and chronic diabetic microvascular complications, and their applications in diabetes mellitus. Organoid technology is expected to further promote the progress of diabetes research in disease modeling, personalized medicine, and regenerative medicine.
