Research progress in the molecular mechanisms of histone deacetylase inhibitors for radiosensitization
10.3760/cma.j.issn.0254-5098.2021.06.012
- VernacularTitle:组蛋白去乙酰化酶抑制剂用于放疗增敏的分子机制研究进展
- Author:
Jie GAO
1
;
Dianjun WEI
;
Jianfeng LIU
;
Chunhua REN
Author Information
1. 中国医学科学院放射医学研究所 天津市放射医学与分子核医学重点实验室 300192
- Keywords:
Radiotherapy;
Radiosensitization;
Histone deacetylase inhibitors;
Selective killing effect
- From:
Chinese Journal of Radiological Medicine and Protection
2021;41(6):465-468
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is one of the most commonly used and effective method to treat malignant tumors in clinical practice. However, there are still some limitations including high radiotherapy doses, harmful side effects on normal tissues, and radiation resistance of tumor cells. Therefore, seeking safe and effective radiotherapy sensitizers to improve radiation sensitivity of tumor cells has been focused for a long time. Histone deacetylase inhibitors (HDACIs), as a kind of epigenetic modifiers, can regulate the sensitivity of tumor cells to ionizing radiation and ultraviolet radiation in addition to the inherent anticancer characteristics. This article reviewed the molecular mechanisms of HDACIs in enhancing radiation sensitivity and by selectively killing tumor cells.
