Research progress in mechanism of H-type vessel on the coupling of angiogenesis and osteogenesis in bone microenvironment remodeling
10.3760/cma.j.cn501098-20210525-00321
- VernacularTitle:H型血管耦联成血管-成骨机制在骨微环境重构机制的研究进展
- Author:
Peisheng CHEN
1
;
Xiaofeng LIN
;
Fengfei LIN
;
Bin CHEN
;
Ke ZHENG
;
Chaohui LIN
Author Information
1. 厦门大学附属福州第二医院骨科，福建医科大学第三临床医学院，福建省创伤骨科急救与康复临床医学研究中心，福州市创伤医学中心 350007
- Keywords:
Endothelial cells;
Osteogenesis;
Signal transduction;
H-type vessels
- From:
Chinese Journal of Trauma
2021;37(11):1048-1054
- CountryChina
- Language:Chinese
-
Abstract:
The coupling effect of angiogenesis and osteogenesis is of great significance for the remodeling of bone microenvironment. As a bone-specific microvascular subtype with high expression of CD31 and Endomucin（CD31 hiEmcn hi），H-type vessels are mainly distributed in the metaphysis，surrounded by Osterix + and Runt-related transcription factor 2（Runx2 +）osteogenic progenitor cells. H-type vessels，regulated by vascular endothelial growth factor（VEGF），platelet-derived growth factor BB（PDGF-BB），slit guidance ligand 3（SLIT3），hypoxia inducible factor 1α（HIF-1α），Notch and other signals，participate in the regulation of cell proliferation and differentiation of bone marrow mesenchymal stem cells（BMSCs），osteoblasts，osteoclasts，endothelial cells，etc. The mechanism of H-type vessels in coupling osteogenesis with angiogenesis has become a hot spot in recent research. The authors explore the progress of the mechanism of H-type vessels in coupling osteogenesis with angiogenesis by reviewing the characteristics of H-type vessel，mechanism of H-type vessel regulating bone formation，regulation mechanism of H-type vessel formation and related influencing factors，to provide a reference for clinical bone injury repair and anti-osteoporosis treatment.
