The mediating effect of depression and anxiety between objective cognitive function and subjective memory in patients with epilepsy
10.3760/cma.j.cn371468-20210428-00236
- VernacularTitle:抑郁和焦虑情绪在癫痫患者客观认知功能和主观记忆间的中介作用
- Author:
Xi LIANG
1
;
Hong XU
;
Xinlu LI
;
Chunhua WU
Author Information
1. 昆明医科大学第一附属医院神经内科 650032
- Keywords:
Epilepsy;
Objective cognitive function;
Subjective memory;
Depression;
Anxiety
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2021;30(10):898-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between objective cognitive function and subjective memory in patients with epilepsy and the mediating effect of depression and anxiety.Methods:A total of 123 patients with epilepsy were included, and their basic information and clinical data were collected. The quality of life in epilepsy inventory-89 memory subscale, Beck depression inventory Ⅱ, Beck anxiety scale and repeatable battery for the assessment of neuropsychological status were used to evaluate the subjective memory, depression, anxiety and objective cognitive function of patients with epilepsy. SPSS 25.0 software was used for bivariate correlation analysis and multiple regression analysis, and PROCESS V3.5 macro program was used for Bootstrap mediating effect test.Results:(1)Correlation analysis showed that the objective cognitive function score of patients with epilepsy was negatively correlated with depression score ( r=-0.392, P<0.01) and anxiety score ( r=-0.310, P<0.01), while positively correlated with subjective memory score ( r=0.388, P<0.01). Subjective memory score was significantly negatively correlated with depression score ( r=-0.436, P<0.01) and anxiety score ( r=-0.395, P<0.01). (2)The mediating effects analysis showed that objective cognitive function of patients with epilepsy could affect the subjective memory through the mediating effects of depression and anxiety indirectly. The mediating effect accounted for 33.87% and 17.93% of the total effects respectively. Conclusion:Objective cognitive function, depression and anxiety are closely related to subjective memory in patients with epilepsy. Depression and anxiety play a mediating role between objective cognitive function and subjective memory in patients with epilepsy.
