Effects of anesthesia depth control on cognitive function and high mobility group protein B-1 level in older adult patients with breast cancer
10.3760/cma.j.issn.1008-6706.2021.06.006
- VernacularTitle:麻醉深度控制对老年乳腺癌患者术后认知功能及高迁移率族蛋白B1水平的影响分析
- Author:
Xiaoyan REN
1
;
Yanhua JIANG
;
Lili GUO
;
Jie CHEN
;
Hong MA
Author Information
1. 中国医科大学附属第一医院麻醉科,沈阳 110001
- Keywords:
Anesthesia,general;
Breast neoplasms;
Mastectomy;
Postoperative complications;
Cognition disorders;
High mobility group proteins;
Heart rate;
Blood pressure
- From:
Chinese Journal of Primary Medicine and Pharmacy
2021;28(6):824-829
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of anesthesia depth control on cognitive function and high mobility group protein B1 (HMGB-1) level in older adult patients with breast cancer.Methods:Eighty-six female older adult patients with breast cancer who received mastectomy between June 2019 and June 2020 in the First Hospital of China Medical University, China were included in this study. They were randomly assigned to undergo anesthesia with sodium phenobarbital and atropine at deep (bispectral index 30-45, deep anesthesia group, n = 43) or superficial level (bispectral index 45-60, superficial anesthesia group, n = 43). The mean arterial pressure, heart rate, HMGB-1 level, Mini-Mental State Examination (MMSE) score were assessed in each group. Results:There were no significant differences in mean arterial pressure and heart rate recorded during each time period between the deep anesthesia and superficial anesthesia groups (all P > 0.05). No significant difference in HMGB-1 level was found between the two groups before anesthesia induction and at the end of surgery (both P > 0.05). At 1 and 2 days after surgery, HMGB-1 level in the deep anesthesia group was (75.46 ± 3.33) pg/mL and (93.98 ± 4.32) pg/mL, respectively, which was significantly lower than that in the superficial anesthesia group [(87.89 ± 5.13) pg/mL and (121.01 ± 4.36) pg/mL, t = 13.327, 28.878, both P < 0.05)]. At 1 day before surgery, there was no significant difference in MMSE score between the two groups ( P > 0.05). In the deep anesthesia group, MMSE score was (26.73 ± 1.11) points, (28.16 ± 0.72) points, and (28.97 ± 0.88) points at 1, 3 and 6 days after surgery respectively, which was significantly higher than that in the superficial anesthesia group [(21.03 ± 1.46) points, (22.39 ± 1.24) points, and (24.69 ± 0.57) points, t = 20.380, 26.388, 26.768, all P < 0.05]. Conclusion:Deep anesthesia for mastectomy in older adult patients can reduce cognitive impairment and decrease HMGB-1 level after surgery, and plays a positive role in postoperative recovery.
